Noscapine Base

Stability: Stable under normal storage conditions (around 25°C, protected from light)

Pharmacokinetics:

• Absorption: Orally absorbed, but undergoes extensive first-pass metabolism in the liver, resulting in low bioavailability (around 3-5%).
• Distribution: Binds extensively to plasma proteins.
• Metabolism: Extensively metabolized in the liver to various metabolites, mostly inactive.
• Elimination: Primarily eliminated through the feces, with a small amount excreted in the urine.
• Half-life: Approximately 6-8 hours.

Pharmacological Actions:

• Antitussive: Suppresses cough reflex by acting on the cough center in the medulla oblongata.
• Bronchodilatory: Relaxes bronchial smooth muscle, but the effect is weak and of limited clinical significance.
• Vasodilatory: Dilates blood vessels, but the effect is weak and transient.
• Other: Weak analgesic, antihistaminic, and anti-inflammatory effects.