Uthever® Cosmetic

Newly Certified Cosmetic Ingredient 2023, with scientifically validated skincare benefits.

l 1.7 Times Stronger Anti-Wrinkle Effe8ct

l Whitening Effect

l Prevent Skin UVB Damage

l Moisturizing Effect

l Skin repair

l Antioxidant support

About Uthever® Cosmetics

β-Nicotinamide Mononucleotide (NMN) is a derivative of vitamin B3, which plays a crucial role in human cell functions. NMN can be naturally produced in cells or obtained through fruits, vegetables, and poultry. Research shows that NMN is a bioactive compound that can boost cellular NAD+ levels. As we age, NAD+ levels in the body decline, so we need cellular health supplements. Supplementing NAD+ can effectively slow down aging and improve the prevention and management of age-related diseases.

Mechanisms of NMN

l Increase NAD+ levels

l Activate "longevity protein" sirtuins

l Repair DNA damage

l Promote energy production

Best NMN Power, Rising Potent Skincare Ingredient

NMN, short for β-Nicotinamide Mononucleotide, has been scientifically proven to rapidly and effectively increase NAD+ levels in the body. The influence of NMN now spread to the skincare field by targeting multiple pathways and dimensions to maintain skin health.

Uthever®: Newly Certified Cosmetic Ingredient 2023

In February 2023, the China National Medical Products Administration approved the application of Uthever® NMN as a cosmetic ingredient submitted by EffePharm. Uthever® NMN can now be officially used as a cosmetic ingredient and the finished product can be legally marketed and sold.

Enter the Uthever® Scientific Skincare Era

Uthever® NMN

As a clinical-backed NMN brand, Uthever® Cosmetics’ scientifically validated skincare benefits include:

Repairing Skin Barrier

Human Efficacy Trials

Thirty-one healthy female subjects aged 18 to 60 years, all with dry skin, a compromised skin barrier, and transepidermal water loss exceeding 15 g/m²/h, continuously used Uthever® NMN at a concentration of 3% for 14 and 28 days. The results indicated a reduction in transepidermal water loss of 26.23% and 37.60% respectively, demonstrating that Uthever® NMN possesses significant moisturizing properties.

Hydration Benefits

Human Efficacy Trials

Thirty-one healthy female subjects aged 18 to 60 years, all with dry skin, a compromised skin barrier, and transepidermal water loss exceeding 15 g/m²/h, continuously used Uthever® NMN at a concentration of 3% for 14 and 28 days. The results showed that the hydration level of the stratum corneum increased by 32.44% and 54.66%, respectively, indicating that Uthever® NMN has a significant repair effect.

1.7 Times Stronger Anti-Wrinkle Effect

In a controlled experiment targeting wrinkles, using Uthever® NMN at a concentration of 0.625%, the increase in Type I collagen production was 70% higher compared to Vitamin C and Vitamin E. It effectively activates the repair of damaged cells, eliminates ageing cells, promotes the differentiation and regeneration of healthy cells, and creates youthful, firm, and rejuvenated skin.

Prevent Skin UVB Damage

Photodamage is a significant factor in skin aging, and by increasing intermediate filament-related proteins like FLG and IVL, the skin barrier can be fundamentally repaired. Research has found that NMN effectively enhances the levels of FLG and IVL in the skin, repairing the stratum corneum and countering photodamage caused by UVB exposure. This effect was further demonstrated in a study using orally administered Uthever® NMN in mice.

Brighting Effect

As age increases, the number of free radicals rises, leading to reduced skin vitality, loss of elasticity, formation of wrinkles, overall skin aging, dull complexion, and formation of pigmentation. The experimental results in the following figure demonstrate that Uthever® NMN can effectively eliminate free radicals in the skin, restore firm and elastic skin, improve pigmentation, and give the skin a more radiant glow.

Moisturizing Effect

AQP3 is one of the main indicators for measuring skin hydration. In experiments focused on skin moisturization, immunofluorescence is used to track the quantity of AQP3 (as indicated by IOD values in the image below). Uthever® NMN has been proven to increase the number of skin AQP3 at different concentrations, achieving deep hydration effects.